IM vs. SubQ Testosterone Injections: A Complete TRT Comparison
- Gary M. Rudashevsky, NP
- Jul 31
- 4 min read
Updated: Oct 2
Key Takeaways
Both intramuscular (IM) and subcutaneous (SubQ) testosterone injections are clinically effective for treating low testosterone. The best method depends on your personal preference.
SubQ injections are often preferred for their convenience and comfort, as they use a smaller needle and are easier for self-administration.
IM injections can provide higher peak testosterone levels and may require less frequent dosing, making them a good option for those who prefer fewer injections.
Medical supervision is essential regardless of the method you choose to ensure proper dosing, monitor hormone levels, and prevent side effects.
What Is "IM" vs. "SubQ" and Why Is Medical Supervision So Critical?
When a licensed provider prescribes injectable testosterone, they will determine the appropriate route of administration based on your lab work, symptoms, and lifestyle.
Intramuscular (IM): Injected into deep muscle tissue, typically the glute or thigh. This has been the traditional standard for decades.
Subcutaneous (SubQ): Injected into the fatty layer just under the skin, often in the abdomen or upper thigh. This method has gained popularity due to its comfort and ease.
Both methods are supported by clinical research as equally effective. However, testosterone replacement therapy (TRT) should never be self-prescribed or administered without supervision. A licensed medical provider will ensure your safety by overseeing lab work, adjusting dosage, and monitoring for side effects.
The Pros of Intramuscular (IM) Testosterone Injections
Benefits | Considerations |
Time-tested and widely used in clinical practice. | Requires a deeper needle and larger injection volume. |
Delivers high, predictable absorption. | Can be painful or cause injection-site soreness. |
Often cost-effective and familiar to most providers. | May cause hormonal peaks and valleys in sensitive patients. |
Ideal for:
Patients who prefer fewer injections.
Situations where absorption consistency is a priority.
The Pros of Subcutaneous (SubQ) Testosterone Injections
Benefits | Considerations |
Smaller needles mean less discomfort. | Typically requires more frequent injections (2–3 times per week). |
Easier for provider-guided self-administration at home. | Not always suitable for every patient or provider preference. |
Often produces more stable hormone levels with less fluctuation. | Some individuals may experience localized irritation. |
Ideal for:
Patients seeking a more convenient, lower-discomfort option.
Individuals prone to mood swings or energy dips from IM injection cycles.
What Does the Latest Research Say?
The medical community supports both methods as effective for TRT. Recent studies and clinical reviews highlight a few key differences:
A 2014 study published in The Journal of Clinical Endocrinology & Metabolism noted, "Subcutaneous testosterone administration results in physiologic testosterone levels, is well tolerated, and may offer a more convenient alternative to intramuscular administration." [1]
A 2022 study in The Journal of Urology found that subcutaneous testosterone was associated with a more favorable safety profile, with lower post-therapy estradiol and hematocrit levels compared to intramuscular injections. [2]
These findings suggest that while both methods work, SubQ may offer certain advantages, making the choice a matter of individual preference and an informed discussion with your doctor.
Final Thoughts: The Medical Specialists Difference
When it comes to TRT, the method matters, but the medical oversight matters more.
No two bodies are the same, and optimal testosterone therapy depends on continuous care, individualized dosing, and regular lab monitoring.
At Medical Specialists MN in Edina, we take the time to discuss your symptoms, goals, and progress. We provide science-backed, medically supervised hormone replacement therapy designed around you.
📞 Call us at (952) 225-5400 or book a consult below to start your safe, personalized TRT journey with a licensed provider.
Sources Cited:
Scherer, A. M., et al. "A 24-Week Pharmacokinetic and Pharmacodynamic Study of Subcutaneous Testosterone Enanthate Injection in Hypogonadal Men." The Journal of Clinical Endocrinology & Metabolism, vol. 99, no. 12, 2014.
Kovac, J. R., et al. "Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate." The Journal of Urology, vol. 207, no. 1, 2022.
So, Is It Better to Inject Testosterone IM or SubQ?
The Short Answer:
It depends on your individual needs and should be determined by your licensed healthcare provider.
Clinical research supports both IM and SubQ as equally effective delivery methods for testosterone therapy when properly prescribed and administered.
A 2014 study in The Journal of Clinical Endocrinology & Metabolism noted:
“Subcutaneous testosterone administration results in physiologic testosterone levels, is well tolerated, and may offer a more convenient alternative to intramuscular administration.” Read the full study here
Why Medical Supervision Matters More Than Method
Whether you're injecting testosterone IM or SubQ, it's not just about technique. It's about:
Baseline and ongoing lab work
Adjusting dosage based on absorption
Monitoring side effects like hematocrit, estrogen, and PSA
Preventing complications like infection or hormone imbalance
That’s why self-injecting without medical clearance can be risky—even dangerous.
At Medical Specialists of Minnesota, our licensed team oversees every step of your TRT journey. From lab analysis to education on injection technique, you’ll never have to guess
what’s right for you.
Final Thoughts
So, is it better to inject testosterone IM or SubQ?
The method matters, but the medical oversight matters more.
No two bodies are the same, and optimal testosterone therapy depends on continuous care, individualized dosing, and regular lab monitoring.
At Medical Specialists in Edina we take the time with you to talk about your symptoms, your goals , and your progress—we provide science-backed, medically supervised hormone replacement therapy designed around you.
📞 Call us at (952) 225-5400 or book a consult today to start your safe, personalized TRT journey with a licensed provider.
